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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Polyunsaturated Fatty Acids and Cardiovascular Disease

Author(s): Ivan Calzolari, Stefano Fumagalli, Niccolo Marchionni and Mauro Di Bari

Volume 15, Issue 36, 2009

Page: [4094 - 4102] Pages: 9

DOI: 10.2174/138161209789909755

Price: $65

Abstract

Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and antiinflammatory mechanisms underlying their clinical benefits.

Keywords: Polyunsaturated fatty acids, cardiovascular disease, sudden death, coronary heart disease, heart failure


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