Login

Journal Image
Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
VOLUME: 16
ISSUE: 35
DOI: 10.2174/092986709789878238      Price:  $58









Gammadelta T Lymphocytes Producing IFNγ and IL-17 in Response to Candida Albicans or Mycobacterial Antigens: Possible Implications for Acute and Chronic Inflammation

img
Author(s): A. Poggi, S. Catellani, A. Musso and M. R. Zocchi
Pages 4743-4749 (7)
Abstract:
T lymphocytes bearing the γδ T cell receptor are known to play an important role in the first-line defense against viral, bacterial and fungal pathogens. Two main subsets of γδ T cells are known, showing distinct functional behavior: Vδ2 T lymphocytes, circulating in the peripheral blood, are involved in the response to mycobacterial infections and certain viruses, including coxsackie virus B3 and herpes simplex virus type 2. Vδ1 T cells are resident in the mucosalassociated lymphoid tissue and are reported to participate in the immunity against Listeria monocytogenes and cytomegalovirus. Vδ2 T lymphocytes recognize non-peptidic phosphorylated metabolites of isoprenoid biosynthesis, expressed by mycobacteria, while Vδ1 T cells mainly interact with MHC-related antigens (MIC-A and MIC-B) and with receptors, called UL-16 binding proteins, for the UL-16 protein produced by cytomegalovirus-infected cells. Both Vδ1 and Vδ2 T cells can produce interferon-γ in response to MIC-A+ cells or non-peptide antigens, respectively. Moreover, production of TNF-α by human Vγ9/Vδ2 T cells has been demonstrated in response to bacterial products and non-peptidic molecules. Recently, it has been reported that γδ T lymphocytes can produce IL-17 during Escherichia coli or Mycobacterium tuberculosis infections in mice. This is of interest as IL-17 is emerging as a cytokine crucial in the control of intracellular pathogens and fungi. In this review, we will discuss the possible role of IL-17 producing γδ T cells in the regulation of acute and chronic inflammation, focusing on the different responses of the two subsets to mycobacterial, viral or fungal antigens.
Keywords:
γδ T lymphocytes, fungal infections, phosphate antigens, CD161, cytokines
Affiliation:
Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 60, 20132-Milan, Italy.