Second Messenger Modulation: A Novel Target of Future Antidepressants?

Author(s): D. Marazziti, M. Catena Dell'Osso, G. Consoli, S. Baroni.

Journal Name: Current Medicinal Chemistry

Volume 16 , Issue 35 , 2009

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Abstract:

During the transduction of extracellular signals within the cell, the stimulation of specific G protein-coupled receptors (GPCRs) can modulate adenylyl or guanylyl cyclase, phospholipase C activity and ion channels, which regulate second-messengers. These, in turn, trigger several biochemical cascades, including Ca2+ release, activation of protein kinases and gene expression. Significant changes of monoamine GPCR activity may occur in patients suffering from mood disorders and the majority of antidepressants exert part of their effects through GPCR-mediated systems. The main signal transduction pathways activated by metabotropic receptors in the brain and their possible involvement in the pathophysiology of mood disorders will be reviewed herein with a special focus on the horizons opened by this approach in terms of innovative therapeutic strategies.

Keywords: G protein-coupled receptors, central nervous system, adenylyl cyclase, guanylyl cyclase, phospholipase C, mood disorders, antidepressants

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Article Details

VOLUME: 16
ISSUE: 35
Year: 2009
Page: [4679 - 4690]
Pages: 12
DOI: 10.2174/092986709789878184
Price: $58

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