Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

Back

A Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis

Author(s): Yoshiro Maru.

Abstract:

Provoked by the discovery of metastasis-inducing endogenous ligands of TLR4 that has been recognized as a sensor for extrinsic pathogens, I propose an extended concept for danger signal that originally meant sentinels over tissue destruction by cancer. The so-called “homeostatic inflammation” concept includes signals before destruction actually takes place such as those in pre-metastatic microenvironment and possibly even in physiological conditions. It is orchestrated by tight cross-talks between growth factor and chemokine signaling.

Keywords: S100A8, SAA3, TLR4, metastasis, pre-metastasis, inflammation, homeostasis

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 4
Year: 2009
Page: [337 - 347]
Pages: 11
DOI: 10.2174/187152309789839064
Price: $58