Novel Therapeutic Targets for Prevention and Therapy of Sepsis Associated Acute Kidney Injury

Author(s): Christian H. Pelte , Lakhmir S. Chawla .

Journal Name: Current Drug Targets

Volume 10 , Issue 12 , 2009

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Abstract:

Sepsis associated Acute Kidney Injury (SA-AKI) is the leading cause of AKI in the hospital setting and its incidence is increasing. Although the exact pathophysiology and phenotype of SA-AKI are not known, it is widely accepted that SA-AKI has a multi-injury pathway. This form of AKI has components of ischemia-reperfusion injury, direct inflammatory injury, coagulation and endothelial cell dysfunction, and apoptosis. As such, multiple agents have been shown in pre-clinical studies to ameliorate SA-AKI, but there are no interventions currently available for the treatment of SA-AKI. Promising agents that are in development include toll-like receptor inhibition, IL-10 augmentation, modulators of the protein C pathway, and mesenchymal stem cell mediated therapeutics. The aim of this review is to review the pathophysiology of SA-AKI and the therapeutic interventions that are under development to treat this complex and morbid disease.

Keywords: Sepsis associated acute kidney injury, inflammation, IL-6, toll-like receptors, IL-10, ischemia reperfusion injury, apoptosis, activated protein C, soluble thrombomodulin, ethyl pyruvate

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Article Details

VOLUME: 10
ISSUE: 12
Year: 2009
Page: [1205 - 1211]
Pages: 7
DOI: 10.2174/138945009789753219
Price: $58

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