Abstract
Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.
Current Gene Therapy
Title: Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes
Volume: 9 Issue: 5
Author(s): Juan F. Vera, Malcolm K. Brenner and Gianpietro Dotti
Affiliation:
Abstract: Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.
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Vera F. Juan, Brenner K. Malcolm and Dotti Gianpietro, Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes, Current Gene Therapy 2009; 9 (5) . https://dx.doi.org/10.2174/156652309789753338
DOI https://dx.doi.org/10.2174/156652309789753338 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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