Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

Author(s): Juan F. Vera, Malcolm K. Brenner, Gianpietro Dotti.

Abstract:

Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2009
Page: [396 - 408]
Pages: 13
DOI: 10.2174/156652309789753338
Price: $58