Targeting Prostate Cancer Stem Cells

Author(s): Francesco Crea, Lesley A. Mathews, William L. Farrar, Elaine M. Hurt.

Journal Name:Anti-Cancer Agents in Medicinal Chemistry

Volume 9 , Issue 10 , 2009

Abstract:

Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

Keywords: Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin

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Article Details

VOLUME: 9
ISSUE: 10
Year: 2009
Page: [1105 - 1113]
Pages: 9
DOI: 10.2174/187152009789735053
Price: $58