Targeting Prostate Cancer Stem Cells
Francesco Crea, Lesley A. Mathews, William L. Farrar and Elaine M. Hurt
Pages 1105-1113 (9)
Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.
Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin
Laboratory of Cancer Prevention, NCI-Frederick, 1050 Boyles Street, Building 560, Room 21-81, USA.