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Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
ISSN (Print): 1871-5206
ISSN (Online): 1875-5992
VOLUME: 9
ISSUE: 10
DOI: 10.2174/187152009789735053      Price:  $58









Targeting Prostate Cancer Stem Cells

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Author(s): Francesco Crea, Lesley A. Mathews, William L. Farrar and Elaine M. Hurt
Pages 1105-1113 (9)
Abstract:
Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.
Keywords:
Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin
Affiliation:
Laboratory of Cancer Prevention, NCI-Frederick, 1050 Boyles Street, Building 560, Room 21-81, USA.