Determination of Clopidogrel by Chromatography

Author(s): Lenka Vocilkova , Radka Opatrilova , Vladimir Sramek .

Journal Name: Current Pharmaceutical Analysis

Volume 5 , Issue 4 , 2009

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Abstract:

Clopidogrel, being a potent platelet aggregation inhibitor, is used widely around the world to reduce cardiovascular risks in patients with stroke, myocardial infarction, and atherosclerosis. The aim of this review firstly focuses on a comprehensive update of chromatography determination of clopidogrel and its metabolites as well as in human plasma, Wistar rat plasma, and in pharmaceutical preparations. It has been described using TLC, HPLC/MS, RP-HPLC, and GC/MS methods. Secondly to localize the chromatography conditions for separation and quantification, this review provides detailed information on separation conditions for clopidogrel and its metabolites. A new HPLC method adjusted to our laboratory conditions was developed for the evaluation of assay and purity of clopidogrel in film-coated tablets.

Keywords: Clopidogrel, HPLC, Tablets

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2009
Page: [424 - 431]
Pages: 8
DOI: 10.2174/157341209789649131
Price: $58

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