Abstract
Clopidogrel, being a potent platelet aggregation inhibitor, is used widely around the world to reduce cardiovascular risks in patients with stroke, myocardial infarction, and atherosclerosis. The aim of this review firstly focuses on a comprehensive update of chromatography determination of clopidogrel and its metabolites as well as in human plasma, Wistar rat plasma, and in pharmaceutical preparations. It has been described using TLC, HPLC/MS, RP-HPLC, and GC/MS methods. Secondly to localize the chromatography conditions for separation and quantification, this review provides detailed information on separation conditions for clopidogrel and its metabolites. A new HPLC method adjusted to our laboratory conditions was developed for the evaluation of assay and purity of clopidogrel in film-coated tablets.
Keywords: Clopidogrel, HPLC, Tablets
Current Pharmaceutical Analysis
Title: Determination of Clopidogrel by Chromatography
Volume: 5 Issue: 4
Author(s): Lenka Vocilkova, Radka Opatrilova and Vladimir Sramek
Affiliation:
Keywords: Clopidogrel, HPLC, Tablets
Abstract: Clopidogrel, being a potent platelet aggregation inhibitor, is used widely around the world to reduce cardiovascular risks in patients with stroke, myocardial infarction, and atherosclerosis. The aim of this review firstly focuses on a comprehensive update of chromatography determination of clopidogrel and its metabolites as well as in human plasma, Wistar rat plasma, and in pharmaceutical preparations. It has been described using TLC, HPLC/MS, RP-HPLC, and GC/MS methods. Secondly to localize the chromatography conditions for separation and quantification, this review provides detailed information on separation conditions for clopidogrel and its metabolites. A new HPLC method adjusted to our laboratory conditions was developed for the evaluation of assay and purity of clopidogrel in film-coated tablets.
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Cite this article as:
Vocilkova Lenka, Opatrilova Radka and Sramek Vladimir, Determination of Clopidogrel by Chromatography, Current Pharmaceutical Analysis 2009; 5 (4) . https://dx.doi.org/10.2174/157341209789649131
DOI https://dx.doi.org/10.2174/157341209789649131 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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