Genome-Wide Association Studies of Family Data in Pharmacogenetics: A Case Study

Author(s): Amy Murphy , Jessica Lasky-Su , Kelan G. Tantisira , Augusto A. Litonjua , Christoph Lange , Scott T. Weiss .

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 32 , 2009

Abstract:

Genome-wide associations studies (GWAS) have become routine in human genetics research; however the application of GWAS to pharmacogenomics research is just beginning. As these studies make their way into pharmacogenetics, there are several considerations specific to pharmacogenetics that should be made. In this manuscript, we discuss these considerations and provide concrete examples with GWAS data for an asthma clinical trial using parentoffspring trios.

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Article Details

VOLUME: 15
ISSUE: 32
Year: 2009
Page: [3764 - 3772]
Pages: 9
DOI: 10.2174/138161209789649493
Price: $58

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