Synthesis of Tetrahydropyrimidine Derivatives and its Glycosides

Author(s): Wesam S. Shehab.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 18 , 2009

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Abstract:

Ethyl-4-thienyl-6-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine carboxyl ate (4) was obtained by the reaction of thiophene-2-carbaldehyde, urea and ethylbenzoylacetate. Reaction of (4) with phosphorous oxy chloride followed by hydrazine hydrate afforded the hydrazide (6), condensation of (6) with D-glucose followed by acetylation gave the acetylated compound (8), which cyclized into triazolopyrimidine derivatives (9) in presence of bromine/acetic acid the deprotection of compound (9) in presence of TEA/MeOH afforded the deprotected compound (10). Selected members of the compounds were screened for antimicrobial activity.

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Article Details

VOLUME: 13
ISSUE: 18
Year: 2009
Page: [1848 - 1851]
Pages: 4
DOI: 10.2174/138527209789630451
Price: $58

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