Abstract
Fluorinated compounds play a unique role in the development of novel lead compounds in both medicinal chemistry and modern crop protection. The introduction of fluorine atom always produces significant changes in the physical properties and often improves the biological activity of target moleculars. Multicomponent reactions (MCRs) are becoming a vastly more powerful tool for the creation of molecule libraries due to their highly convergent diversity, efficiency, selectivity, and atom economy. This paper reviewed growing applications of the trifluoromethyl, difluoromethyl, and fluoroalkyl building blocks as one of components in the multicomponent reactions for the construction of complex and diverse fluorinated molecules, respectively.
Current Organic Chemistry
Title: Multicomponent Reactions Based on Fluoro-Containing Building Blocks
Volume: 13 Issue: 18
Author(s): Jingjing Wu and Song Cao
Affiliation:
Abstract: Fluorinated compounds play a unique role in the development of novel lead compounds in both medicinal chemistry and modern crop protection. The introduction of fluorine atom always produces significant changes in the physical properties and often improves the biological activity of target moleculars. Multicomponent reactions (MCRs) are becoming a vastly more powerful tool for the creation of molecule libraries due to their highly convergent diversity, efficiency, selectivity, and atom economy. This paper reviewed growing applications of the trifluoromethyl, difluoromethyl, and fluoroalkyl building blocks as one of components in the multicomponent reactions for the construction of complex and diverse fluorinated molecules, respectively.
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Cite this article as:
Wu Jingjing and Cao Song, Multicomponent Reactions Based on Fluoro-Containing Building Blocks, Current Organic Chemistry 2009; 13 (18) . https://dx.doi.org/10.2174/138527209789630460
DOI https://dx.doi.org/10.2174/138527209789630460 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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