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Current Drug Targets
ISSN (Print): 1389-4501
ISSN (Online): 1873-5592
VOLUME: 10
ISSUE: 10
DOI: 10.2174/138945009789578007      Price:  $58









Efficacy and Safety of the Combination of Docetaxel (Taxotere®) with Targeted Therapies in the Treatment of Solid Malignancies

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Author(s): Vincenzo Emanuele Chiuri, Nicola Silvestris, Andrea Tinelli and Vito Lorusso
Pages 982-1000 (19)
Abstract:
Docetaxel is a chemotherapeutic drug which has recently demonstrated high efficacy in the treatment of a wide variety of tumors. Numerous novel targeted drugs are being introduced in preclinical and clinical practice, aiming to directly inhibit pathways responsible for the maintenance of transformed and immortalized phenotypes of cancer cells. Herein we reported the efficacy and safety results of the most significant clinical trials evaluating different combinations and schedules of docetaxel plus biological therapeutics.
Keywords:
Docetaxel, targeted therapy, solid tumors, EGFR, PDGFR, VEGFR, RTKI, BCL-2, safety, efficacy
Affiliation:
Oncologia Medica, Ospedale ‘V. Fazzi’, P.zza F. Muratore, 73100 Lecce, Italy.