Reactions, Anti-Alzheimer and Anti COX-2 Activities of the Newly Synthesized 2-Substituted Thienopyridines

Author(s): Fawzy A. Attaby , Azza M. Abdel-Fattah , Labeeb M. Shaif , Mohamed M. Elsayed .

Journal Name: Current Organic Chemistry

Volume 13 , Issue 16 , 2009

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3-Amino-4-(phenyl or p-methoxyphenyl)-6-pyridin-3-ylthieno[2,3-b]-pyridine-2-carboxamide and 3-amino-4- (phenyl or p-methoxyphenyl)-6-pyridin-3-ylthieno[2,3-b]pyridine-2-carbonitrile were used as the starting materials aiming to obtain the newly synthesized pyridothieno-pyrimidines, pyridothienotriazines and pyridothienoxazines via their reactions with several reagents e.g. CS2, HCOOH, CH(OEt)3, Ac2O and HNO2. These newly synthesized heterocyclic compounds were tested as anti-Alzheimer and anti COX-2 agents and their structures were elucidated by considering the data of IR, 1H NMR, mass spectra and elemental analyses.

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Article Details

Year: 2009
Page: [1654 - 1663]
Pages: 10
DOI: 10.2174/138527209789578135
Price: $58

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