Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs
Xiaohui Pu, Jin Sun, Mo Li and Zhonggui He
Affiliation: No. 59 Mailbox, Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China.
Nanosuspensions have attracted much interest of many scientists as a new approach to deliver poorly soluble drugs because of their process flexibility and special advantages such as improved oral bioavailability, high drug loading, targeting capabilities and so on. Recently, the manufacture processes of nanosuspensions have developed quickly, and some new methods have emerged, for example, controlled precipitation, emulsion method, microemulsion method and melt-emulsion method. Additionally, the post-process of nanosuspension has also gained great progresses to expand the utility of nanosuspensions, including solidification technique and surface modification technique. Moreover, the study on targeting delivery by nanosuspension following intravenous administration has become a hot topic of many researches. In the article, we will highlight new developments in the production of nanosuspensions and summarize the application of nanosuspensions via a variety of administration routes. In the end, we will overview the research and development prospectives of nanosuspensions.
Keywords: Nanosuspension, poorly soluble drugs, bioavailability, layer-by-layer self-assembly, targeting
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