Novel Chiral Catalysts for Asymmetric Addition of Terminal Alkynes to Aldehydes

Author(s): Jincheng Mao, Guanlei Xie.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 15 , 2009

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Abstract:

There is growing interest in enantioselective synthesis of optically active propargylic alcohols. One of the most effective and straightforward ways for their synthesis is asymmetric addition of terminal alkynes to aldehydes. In the past several years, various combinations of novel chiral ligands and transition metal sources have been employed as catalysts in this asymmetric alkynylation reaction. In this review, we highlight the recent advances in this field and try to compare the methods available for this transformation.

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Article Details

VOLUME: 13
ISSUE: 15
Year: 2009
Page: [1553 - 1564]
Pages: 12
DOI: 10.2174/138527209789177707
Price: $58

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