Asymmetric Alkynylation Reactions of Aldehydes Using a Zn(OTf)2-Chiral Ligand-Base System

Author(s): Elizabeth Tyrrell.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 15 , 2009

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Abstract:

Optically active propargylic alcohols serve as an important building block in asymmetric synthesis. The customised synthesis of chiral ligands and transition metal activators as catalysts, to effect asymmetric alkynylation reactions, continue to feature in the literature. This review article focuses upon the use of Zn(OTf)2, in conjunction with 2-point chiral ligands, for effecting asymmetric alkynylation reactions to aldehydes.

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Article Details

VOLUME: 13
ISSUE: 15
Year: 2009
Page: [1540 - 1552]
Pages: 13
DOI: 10.2174/138527209789177716
Price: $58

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