Recent Developments in Asymmetric Alkynylation of Imines

Author(s): G. Blay, A. Monleon, J. R. Pedro.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 15 , 2009

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Abstract:

This review deals with the asymmetric alkynylation of imines (and iminium ions) to give chiral nonracemic propargylamines. Diastereoselective procedures involved the addition of metal alkynylides to chiral nonracemic imines derived from chiral amines or chiral carbonyl compounds. Enantioselective non-catalytic procedures have been achieved with the use of stoichiometric additives or alkynylboron reagents. Finally, catalytic addition of terminal alkynes or zinc acetylides has been carried out in the presence of chiral metal complexes, especially copper complexes as catalysts.

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Article Details

VOLUME: 13
ISSUE: 15
Year: 2009
Page: [1498 - 1539]
Pages: 42
DOI: 10.2174/138527209789177734
Price: $58

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