Pharmacogenomics – Implications in the Development of HIV-Associated Brain Disease

Author(s): Thorsten Nolting , Gabriele Arendt .

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 8 , Issue 2 , 2009

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Abstract:

Pharmacogenomics is a relatively new field in HIV-research, especially when neurological issues are concerned. Influence of polymorphisms in CYP3A4, CYP2B6, CYP2D6, ABCB1, ABCG2, ABCC4, SLC22, SLC28, SLC29 and MMP9-genes on pharmacokinetic data is discussed in the article. Due to the lack of published studies, but promising results in the few existing publications, scientists should be encouraged to integrate neurological aspects in pharmacogenomics research.

Keywords: HIV, CNS, pharmacogenomics, pharmacogenetics, MMP9, SLC, ABC-transporter, cytochrome

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2009
Page: [164 - 168]
Pages: 5
DOI: 10.2174/187152309789152101
Price: $58

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