Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

Author(s): Erika C. Claud

Affiliation: University of Chicago, Department of Pediatrics and Medicine, Section of Neonatology and Gastroenterology, 5841 S. Maryland Ave MC6060, Chicago, IL 60637, USA.

Abstract:

Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.

Keywords: Neonatal necrotizing enterocolitis, premature infant, probiotic, human milk, platelet activating factor, nuclear factor kappaB

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Article Details

VOLUME: 8
ISSUE: 3
Page: [248 - 259]
Pages: 12
DOI: 10.2174/187152309789152020
Price: $58