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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)
ISSN (Print): 1871-5230
ISSN (Online): 1875-614X
VOLUME: 8
ISSUE: 3
DOI: 10.2174/187152309789152020      Price:  $58









Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

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Author(s): Erika C. Claud
Pages 248-259 (12)
Abstract:
Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.
Keywords:
Neonatal necrotizing enterocolitis, premature infant, probiotic, human milk, platelet activating factor, nuclear factor kappaB
Affiliation:
University of Chicago, Department of Pediatrics and Medicine, Section of Neonatology and Gastroenterology, 5841 S. Maryland Ave MC6060, Chicago, IL 60637, USA.