Abstract
The N, N dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues. As Polycystic Ovary Syndrome (PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome- the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
Keywords: Polycystic ovary syndrome (PCOS), metformin, diabetes, adolescents, pregnancy, ovulation, cardiovascular
Current Pharmaceutical Design
Title: Mechanisms Involved in Metformin Action in the Treatment of Polycystic Ovary Syndrome
Volume: 15 Issue: 26
Author(s): A. B. Motta
Affiliation:
Keywords: Polycystic ovary syndrome (PCOS), metformin, diabetes, adolescents, pregnancy, ovulation, cardiovascular
Abstract: The N, N dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues. As Polycystic Ovary Syndrome (PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome- the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
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Cite this article as:
Motta B. A., Mechanisms Involved in Metformin Action in the Treatment of Polycystic Ovary Syndrome, Current Pharmaceutical Design 2009; 15 (26) . https://dx.doi.org/10.2174/138161209789058101
DOI https://dx.doi.org/10.2174/138161209789058101 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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