Abstract
Lipid matrix nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), have been sought as a useful alternative for formulating poorly soluble drugs intended for several administration routes, e.g. oral, parenteral and topical. These systems are surfaced by a film of surfactant in an aqueous phase, being therefore physicochemically and thermodynamically stable having a mean particle size below 1 µm. The matrix of SLN is solely composed of a pure solid lipid (melting point above 40°C) whereas NLC is composed of a blend of solid and liquid lipids, which must also be solid at both body and room temperatures. The achievements of SLN and NLC as drug carrier systems are due to several advantages, e.g. incorporation of hydrophobic and hydrophilic drug molecules (including peptides and proteins), controlled release, protection of chemically labile drugs, fulfil several prerequisites for an optimum colloidal drug carrier. The present review aims to emphasize the special features of lipid matrix nanoparticles, in particular for controlled release purposes. An overview on pharmacokinetic and biopharmaceutic results achieved by different research groups is given and their parameters are analyzed.
Keywords: Lipid nanoparticles, lipid polymorphism, controlled release, oral, parenteral, topical
Current Nanoscience
Title: Lipid Matrix Nanoparticles: Pharmacokinetics and Biopharmaceutics
Volume: 5 Issue: 3
Author(s): Doktorovova S., Gokce E., Ozyazici M. and Souto E. B.
Affiliation:
Keywords: Lipid nanoparticles, lipid polymorphism, controlled release, oral, parenteral, topical
Abstract: Lipid matrix nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), have been sought as a useful alternative for formulating poorly soluble drugs intended for several administration routes, e.g. oral, parenteral and topical. These systems are surfaced by a film of surfactant in an aqueous phase, being therefore physicochemically and thermodynamically stable having a mean particle size below 1 µm. The matrix of SLN is solely composed of a pure solid lipid (melting point above 40°C) whereas NLC is composed of a blend of solid and liquid lipids, which must also be solid at both body and room temperatures. The achievements of SLN and NLC as drug carrier systems are due to several advantages, e.g. incorporation of hydrophobic and hydrophilic drug molecules (including peptides and proteins), controlled release, protection of chemically labile drugs, fulfil several prerequisites for an optimum colloidal drug carrier. The present review aims to emphasize the special features of lipid matrix nanoparticles, in particular for controlled release purposes. An overview on pharmacokinetic and biopharmaceutic results achieved by different research groups is given and their parameters are analyzed.
Export Options
About this article
Cite this article as:
S. Doktorovova, E. Gokce, M. Ozyazici and B. E. Souto, Lipid Matrix Nanoparticles: Pharmacokinetics and Biopharmaceutics, Current Nanoscience 2009; 5 (3) . https://dx.doi.org/10.2174/157341309788921516
DOI https://dx.doi.org/10.2174/157341309788921516 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
State of the Art of Nanobiotechnology Applications in Neglected Diseases
Current Nanoscience Management of Hypertension in Relation to Acute Coronary Syndromes and Revascularisation
Current Pharmaceutical Design Targeting Heme Oxygenase-1 in Vascular Disease
Current Drug Targets Hesperidin Potentiates Ghrelin Signaling
Recent Patents on Food, Nutrition & Agriculture Susceptibility of Helicobacter pylori to Natural Products: Can Past Research Direct Future Drug Development?
Current Bioactive Compounds Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review
Current Medicinal Chemistry β-Lactam Cholesterol Absorption Inhibitors
Current Medicinal Chemistry Cognitive and Cardiovascular Benefits of Docosahexaenoic Acid in Aging and Cognitive Decline
Current Alzheimer Research Telomere Length Variations in Aging and Age-Related Diseases
Current Aging Science Pharmacological Modulation of Nitric Oxide Release: New Pharmacological Perspectives, Potential Benefits and Risks
Current Medicinal Chemistry Current & Future Therapies of Erectile Dysfunction in Neurological Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Retracted: Potential Health Benefits of Broccoli- A Chemico-Biological Overview
Mini-Reviews in Medicinal Chemistry Impact of Mitochondrial Toxicity of HIV-1 Antiretroviral Drugs on Lipodystrophy and Metabolic Dysregulation
Current Pharmaceutical Design Biomedical Applications of Superparamagnetic Nanoparticles in Molecular Scale
Current Organic Chemistry Novel Pharmacologic Approaches to the Management of Sepsis: Targeting the Host Inflammatory Response
Recent Patents on Inflammation & Allergy Drug Discovery SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-Related Vascular Diseases
Current Molecular Medicine Utility of Anti-Arrhythmic Medications in ‘Lone Atrial Fibrillation’
Current Pharmaceutical Design Interstitial Lung Disease Associated with Collagen Vascular Disease
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) GPER and ER: Estrogen Receptors with Distinct Biological Roles in Breast Cancer
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Nicotinamide Adenine Dinucleotide Based Therapeutics
Current Medicinal Chemistry