Recent Advances in the Discovery and Development of Novel HIV-1 NNRTI Platforms: 2006-2008 Update

Author(s): Peng Zhan, Xinyong Liu, Zhenyu Li.

Journal Name: Current Medicinal Chemistry

Volume 16 , Issue 22 , 2009

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Abstract:

Currently, the long-term usage of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIV/AIDS patients eventually leads to the development of drug resistance and severe side effect. Therefore, it is imperative to look for the novel NNRTIs with potent and broad spectrum anti-mutant activity that are also safe and have excellent pharmacokinetic profiles. In this article, newly emerging NNRTIs scaffolds in recent three years, together with the underlying strategies for developing new generation HIV-1 NNRTIs with improved resilience to current drug resistant mutants, are reviewed and analysed.

Keywords: HIV, AIDS, NNRTIs, drug resistance, inhibitor, drug design

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Article Details

VOLUME: 16
ISSUE: 22
Year: 2009
Page: [2876 - 2889]
Pages: 14
DOI: 10.2174/092986709788803231
Price: $58

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