2-Isocyanatobenzonitrile and 2-Isothiocyanatobenzonitrile - Versatile Building Blocks in Organic Synthesis

Author(s): Franziska Bendrath, Peter Langer.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 10 , 2009

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Abstract:

2-Isothiocyanatobenzonitrile (ITCB) and isocyanatobenzonitrile (ICB) represent versatile difunctional building blocks containing a nitrile and an isothiocyanate or an isocyanate function, respectively. The present review provides an account of the chemistry of ITCB and ICB. This includes a number of one-pot cyclizations which provide a convenient access to a variety of pharmacologically important heterocycles.

Keywords: 2-Isothiocyanatobenzonitrile (ITCB), isocyanatobenzonitrile (ICB), Organic Synthesis, Building Blocks, isocyanate function, one-pot cyclizations, heterocycles

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2009
Page: [955 - 964]
Pages: 10
DOI: 10.2174/138527209788680763
Price: $58

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