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Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
VOLUME: 16
ISSUE: 20
DOI: 10.2174/092986709788682047      Price:  $58









Cerebral Amyloid Angiopathy: A Common Cause of Cerebral Hemorrhage

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Author(s): A. Pezzini, E. Del Zotto, I. Volonghi, A. Giossi, P. Costa and A. Padovani
Pages 2498-2513 (16)
Abstract:
Amyloid is a term used to describe protein deposits with circumscript physical characteristics: β-pleated sheet configuration, apple green birefringence under polarized light after Congo red staining, fibrillary structure and high insolubility. Cerebral amyloid angiopathy (CAA) defines a clinicopathological phenomenon characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and, less often capillaries and veins of the central nervous system. CAAs are currently classified according to the protein deposited including amyloid β peptide (Aβ), cystatin C (ACys C), prion protein (PrPSc), ABri/ADan, transthyretin (ATTR), and gelsolin (AGel). Most often amyloid deposition occurs in sporadic forms. In less common hereditary forms, a mutated variant protein or precursor protein is abnormally metabolized by proteolytic pathways in consequence of specific gene mutations, and accumulates as amyloid. The spectrum of clinical phenotypes associated with CAA-related vasculopathic changes includes both ischemic and hemorrhagic presentations, primary intracerebral hemorrhage (PICH) being probably the most well-recognized. However, in spite of accumulating data and recent progress in understanding the pathogenesis of CAA-related hemorrhage, the exact mechanisms leading to vessel rupture in these cases are yet to be established. This represents, at present, a major limitation to the identification of reliable biomarkers and the development of disease-specific treatment options. The present paper summarizes epidemiologic and clinical aspects of CAA, and highlights the presumed pathomechanisms of amyloid deposition in both sporadic and hereditary forms.
Keywords:
Cerebral amyloid angiopathy, intracerebral hemorrhage, β amyloid peptide, hereditary cerebral hemorrhage with amyloidosis
Affiliation:
Neurology Clinic, University of Brescia, P.le Spedali Civili, 1, 25125 Brescia, Italy.