Abstract
Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimers disease and as antitumour agents.
Keywords: 2-Arylbenzothiazoles, synthesis, Alzheimer's disease diagnosis, positron emission tomography, antitumour agents
Current Medicinal Chemistry
Title: 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery
Volume: 16 Issue: 19
Author(s): A. A. Weekes and A. D. Westwell
Affiliation:
Keywords: 2-Arylbenzothiazoles, synthesis, Alzheimer's disease diagnosis, positron emission tomography, antitumour agents
Abstract: Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimers disease and as antitumour agents.
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Cite this article as:
Weekes A. A. and Westwell D. A., 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery, Current Medicinal Chemistry 2009; 16 (19) . https://dx.doi.org/10.2174/092986709788682137
DOI https://dx.doi.org/10.2174/092986709788682137 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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