Anti-Infective Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Infective Agents)

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Interaction between Phenols and Bovine Serum Albumin

Author(s): Yuanzhi Song, Jimin Xie, Yunlong Wu, Min Chen, Ganqing Zhao, Xiaomeng Lv, Huoming Shu, Songtao Chen.

Abstract:

The interactions between bovine serum albumin and phenols have been studied by cyclic voltammetry (CV). The interaction divides into specific and non-specific binding sites, and mainly ascribes to the electronic force. One specific binding site between bovine serum albumin and p-aminophenol (p-AP) as well as p-quinonimine (p-AQ) is obtained. Both the specific binding number of p-AP and p-AQ binding bovine serum albumin were in the ratio of 5:1. Two specific binding sites for p-hydroquinone (p-HQ) and p-benzoquinone (p-BQ) were found, respectively. The specific binding number of p-HQ are 15:1 and 9:1, respectively, while total specific binding number was 26:1. Moreover, the specific binding number of p-BQ was 15:1 and 9:1, respectively, with total specific binding number was 26:1. Three specific binding sites for pyrocatechol (PC) were obtained, and two specific binding sites for o-benzoquinone (o-BQ) were observed. The specific binding number of PC are 11:1, 3:1 and 8:1, respectively, total specific binding number being 22:1. However, the specific binding number of o-BQ was 3:1 and 5:1 respectively, with total specific binding number being 8:1.

Keywords: Phenols, bovine serum albumin, interaction, electrochemistry

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2009
Page: [268 - 271]
Pages: 4
DOI: 10.2174/187152109788680234
Price: $58