Anti-Infective Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Infective Agents)

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Antiviral Sesqui-, Di- and Sesterterpenes

Author(s): T. Rezanka, L. Siristova, K. Sigler.

Abstract:

Terpenoids, biosynthetically related ubiquitous compounds found in virtually all living organisms from marine invertebrates to blooming plants, are derived from the same precursor but their structures and biological and/or pharmacological activities are widely different. Our review concerns terpenoid compounds with antiviral activities, from the simplest sesquiterpenes to diterpenes and sesterterpenes. They include commercially produced therapeutics, compounds with documented antiviral effects and potential future medical use, as well as substances in different stages of clinical research and testing. All of them are based on natural compounds, with only partial man-made changes in the basic structure or mere substituent modifications.

Keywords: Terpenoids, natural compounds, Sesterterpenes, Antiviral, pharmacological activities

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2009
Page: [169 - 192]
Pages: 24
DOI: 10.2174/187152109788680225
Price: $58