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Current Analytical Chemistry

Editor-in-Chief

ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Polarographic Determination of Voriconazole in Pharmaceutical Formulations

Author(s): Gianfranco Corbini, Assunta Zanfini, Caterina La Rosa, Alessandro D'Arpino, Racheleb Meucci and Elena Dreassi

Volume 5, Issue 3, 2009

Page: [238 - 243] Pages: 6

DOI: 10.2174/157341109788680282

Price: $65

Abstract

This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.

Keywords: Voriconazole, Vfend, DPP, Tablets, Injectables, Quantitative analysis


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