Polarographic Determination of Voriconazole in Pharmaceutical Formulations

Author(s): Gianfranco Corbini, Assunta Zanfini, Caterina La Rosa, Alessandro D'Arpino, Racheleb Meucci, Elena Dreassi.

Journal Name: Current Analytical Chemistry

Volume 5 , Issue 3 , 2009

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This paper describes a method for voriconazole assay in pharmaceuticals by using differential pulse polarography (DPP). The voriconazole standard was obtained from pharmaceutical formulations and its purity determined by LC/UV, LC/ESI/MS and DSC analyses. In the DPP analysis a well defined peak (-1.01 V, vs. Ag/AgCl), useful for an accurate and precise assay, was obtained using a 0.01 M KH2PO4 water solution (pH 4.5) as supporting electrolyte. The analytical procedure was successfully applied to the voriconazole determination in tablets and injectables.

Keywords: Voriconazole, Vfend, DPP, Tablets, Injectables, Quantitative analysis

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Article Details

Year: 2009
Page: [238 - 243]
Pages: 6
DOI: 10.2174/157341109788680282
Price: $58

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