Title: The Biological Functions of NF-κB1 (p ) and its Potential as an Anti-Cancer Target
VOLUME: 9 ISSUE: 4
Author(s):Yonghui Yu, Yu Wan and Chuanshu Huang
Affiliation:Open Laboratory for Oversea Scientists, Center for Medical Research, Wuhan University, 115 Donghu Rd., Wuhan, Hubei 430071, China.
Abstract: Nuclear factor-κB (NF-κB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-κB1 (p ), NF-κB2 (p ), RelA (p ), RelB and c-Rel. NF-κB is implicated in multiple physiological and pathological processes, including cell proliferation and differentiation, inflammatory and immune response, cell survival and apoptosis, cellular stress reactions and tumorigenesis. Recent studies by our group and others have highlighted the novel functions of the p protein. In this review, we will focus on the regulation and functions of NF-κB p .
