Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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The Biological Functions of NF-κB1 (p ) and its Potential as an Anti-Cancer Target

Author(s): Yonghui Yu, Yu Wan, Chuanshu Huang.

Abstract:

Nuclear factor-κB (NF-κB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-κB1 (p ), NF-κB2 (p ), RelA (p ), RelB and c-Rel. NF-κB is implicated in multiple physiological and pathological processes, including cell proliferation and differentiation, inflammatory and immune response, cell survival and apoptosis, cellular stress reactions and tumorigenesis. Recent studies by our group and others have highlighted the novel functions of the p protein. In this review, we will focus on the regulation and functions of NF-κB p .

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2009
Page: [566 - 571]
Pages: 6
DOI: 10.2174/156800909788486759
Price: $58