Multicomponent One-Pot Reactions: Synthesis of Some New 6-Oxopyrano [2,3-c]Isochromenes by Condensation of Homophthalic Anhydride, Dialkyl acetylenedicarboxylate, and Isocyanides

Author(s): Ali A. Mohammadi, Roya Akbarzadeh, Hamed Rouhi.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 12 , Issue 5 , 2009

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A novel three-component, one-pot condensation of the zwitterion generated from dialkyl acetylenedicarboxylate and isocyanides with homophthalic anhydride is described. The reaction affords new 6-oxopyrano[2,3- c]isochromenes in good yield. Isochromenes have been reported to possess diverse biological activities such as antibacterial, antifungal, antiinflammatory, and antiangiogenic effects. Moreover, Theses important compounds are found in various natural products.

Keywords: Multi-component reaction, isocyanide, dialkyl acetylenedicarboxylate, homophthalic anhydride, isochromenes

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Article Details

Year: 2009
Page: [536 - 542]
Pages: 7
DOI: 10.2174/138620709788489073
Price: $65

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