Metallodrug Conjugates with Steroids and Selective Estrogen Receptor Modulators (SERM)

Title: Metallodrug Conjugates with Steroids and Selective Estrogen Receptor Modulators (SERM)

Volume: 16 Issue: 18

Author(s): B. Biersack and R. Schobert

Affiliation:

Keywords: Targeted metallodrugs, steroids, estrogen receptor, anticancer drugs, selective steroid receptor modulators

Abstract: An overview of conjugates of coordination complexes and organometallic complexes of Pt, Ru, Fe, Re, lanthanoids and other metals with natural and synthetic estrogens and antiestrogens targeting the nuclear estrogen receptors is provided. These conjugates are used as targeted cytotoxic agents or - if radiolabeled - as imaging probes for the detection of estrogen receptor-rich tissues such as hormone-dependent tumours. They are assessed with respect to their estrogen receptor binding affinities, potential synergistic cytotoxic effects in cancer cells and their specificity for tumour over nonmalignant cells and tissues. The mechanisms of their modes of action are discussed. Pertinent literature is covered up to 2008.

Cite this article as:

Biersack B. and Schobert R., Metallodrug Conjugates with Steroids and Selective Estrogen Receptor Modulators (SERM), Current Medicinal Chemistry 2009; 16 (18) . https://dx.doi.org/10.2174/092986709788453050