The Role of ING Tumor Suppressors in UV Stress Response and Melanoma Progression

Author(s): Jun Li, Yemin Wang, Ronald P.C. Wong, Gang Li.

Journal Name: Current Drug Targets

Volume 10 , Issue 5 , 2009

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Abstract:

The INhibitor of Growth (ING) genes were discovered during the past decade and identified as type II tumor suppressor genes. Previous studies demonstrated that ING family members participate in various cellular stress responses and thus play important roles in the pathogenesis of various types of cancers, including melanoma. Epidemiological studies showed that UV radiation is the primary etiological factor in melanoma development. Here we review the studies on the role of ING proteins in cellular responses to UV irradiation, melanoma cell motility, and melanoma progression.

Keywords: ING, tumor suppressor, melanoma, UV irradiation, stress response

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2009
Page: [455 - 464]
Pages: 10
DOI: 10.2174/138945009788185031
Price: $58

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