ING Proteins in Cellular Senescence

Author(s): Camino Menendez, Maria Abad, Daniel Gomez-Cabello, Alberto Moreno, Ignacio Palmero.

Journal Name: Current Drug Targets

Volume 10 , Issue 5 , 2009

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Abstract:

Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2009
Page: [406 - 417]
Pages: 12
DOI: 10.2174/138945009788185077
Price: $58

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