Abstract
Acid Sensing Ion Channels (ASICs) are a family of cation channels expressed principally in neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their distribution in primary sensory neurons points to a significant role of these channels in acid nociception. However, despite the fact that the first ASIC was identified more than 10 years ago the physiological and pathophysiological role of this channel family remains poorly understood. In this paper, the available body of data (genetic, pharmacological, and other) on ASICs will be reviewed and the role of ASIC in normal nociception and other pain sensations will be discussed. Some of the recent drug discovery and development activities ongoing in our laboratory, which point to ASICs being a relevant target for pain modulation, will also be summarized.
Keywords: Acid sensing ion channels, ASIC, tissue acidosis, acid nociception, pain, primary sensory neurons, dorsal root ganglia
Current Pharmaceutical Design
Title: Acid Sensing Ion Channels and Acid Nociception
Volume: 15 Issue: 15
Author(s): G. R. Dube, A. Elagoz and H. Mangat
Affiliation:
Keywords: Acid sensing ion channels, ASIC, tissue acidosis, acid nociception, pain, primary sensory neurons, dorsal root ganglia
Abstract: Acid Sensing Ion Channels (ASICs) are a family of cation channels expressed principally in neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their distribution in primary sensory neurons points to a significant role of these channels in acid nociception. However, despite the fact that the first ASIC was identified more than 10 years ago the physiological and pathophysiological role of this channel family remains poorly understood. In this paper, the available body of data (genetic, pharmacological, and other) on ASICs will be reviewed and the role of ASIC in normal nociception and other pain sensations will be discussed. Some of the recent drug discovery and development activities ongoing in our laboratory, which point to ASICs being a relevant target for pain modulation, will also be summarized.
Export Options
About this article
Cite this article as:
Dube R. G., Elagoz A. and Mangat H., Acid Sensing Ion Channels and Acid Nociception, Current Pharmaceutical Design 2009; 15 (15) . https://dx.doi.org/10.2174/138161209788186263
DOI https://dx.doi.org/10.2174/138161209788186263 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Endothelium and Oxidative Stress: The Pandora's Box of Cerebral (and Non-Only) Small Vessel Disease?
Current Molecular Medicine The Role of Macrophage Migration Inhibitory Factor in Critical Illness
Mini-Reviews in Medicinal Chemistry Adenosine A<sub>2A</sub> Receptor Antagonists as Positron Emission Tomography (PET) Tracers
Current Medicinal Chemistry Gene Therapy in Lung Transplantation
Current Gene Therapy Acute Myocardial Infarction: High Risk Ventricular Tachyarrhythmias and Admission Glucose Level in Patients with and without Diabetes Mellitus
Current Diabetes Reviews Rho Kinase and Angiogenesis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Inflammation Paradigm and Coronary Artery Disease: What Celsus, Virchow and Gene Knock Outs Have Taught Us
Cardiovascular & Hematological Disorders-Drug Targets Kinins and Cardiovascular Diseases
Current Pharmaceutical Design Inflammatory Mechanisms in Myocardial Infarction
Current Drug Targets - Inflammation & Allergy Risk Factors for Heart Failure Progression and Outcomes
Current Cardiology Reviews Anti-atherosclerotic Effects of Spice-Derived Phytochemicals
Current Medicinal Chemistry Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents
Current Medicinal Chemistry Recent Progress and Related Patents on the Applications of Bone Marrow-Derived Stem/Progenitor Cells in Regenerative Medicine and Cancer Therapies
Recent Patents on Regenerative Medicine Pharmacological Characteristics and Clinical Applications of K201
Current Clinical Pharmacology Interest of α2-Adrenergic Agonists and Antagonists in Clinical Practice: Background, Facts and Perspectives
Current Topics in Medicinal Chemistry Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn
Current Drug Metabolism Rho Kinase Inhibitors: Potential Treatments for Diabetes and Diabetic Complications
Current Pharmaceutical Design Neuropeptide Mimetics and Antagonists in the Treatment of Inflammatory Disease: Focus on VIP and PACAP
Current Topics in Medicinal Chemistry Prevention and treatment of atherosclerosis with flaxseed -derived compound secoisolariciresinol diglucoside
Current Pharmaceutical Design Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy
Current Medicinal Chemistry