Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Tripentones: A Promising Series of Potent Anti-Cancer Agents

Author(s): Christophe Rochais, Patrick Dallemagne, Sylvain Rault.

Abstract:

The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol- 9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.

Keywords: Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer

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Article Details

VOLUME: 9
ISSUE: 4
Page: [369 - 380]
Pages: 12
DOI: 10.2174/1871520610909040369
Price: $58