Abstract
Pancreatic cancer is an exceptionally devastating and incurable disease, the treatment of which has largely been unsuccessful due to the higher resistance of pancreatic tumor cells to oncologic treatment. PDAC cells have accumulated different molecular mechanisms, which enable survival against cytotoxic therapies. Defects of the apoptosis pathway play a crucial role. For the last 10 years, many investigations were underway to get insights into the details of the anti-apoptotic mechanisms of PDAC cells. The present review provides a comprehensive description of the molecular signaling of the apoptotic pathway, an incentive on the potential pathogenetic role of different molecular defects on existing oncologic treatments and an appraisal of the most recent therapeutic strategies applied at a cell biochemical level.
Keywords: Apoptosis pathway, pancreatic cancer, targeted therapy, review
Current Cancer Therapy Reviews
Title: Apoptotic Signaling in Pancreatic Cancer – Therapeutic Application (Supplemental Data)
Volume: 5 Issue: 2
Author(s): Felix Ruckert, Christian Pilarsky, Hans-Detlev Saeger and Robert Grutzmann
Affiliation:
Keywords: Apoptosis pathway, pancreatic cancer, targeted therapy, review
Abstract: Pancreatic cancer is an exceptionally devastating and incurable disease, the treatment of which has largely been unsuccessful due to the higher resistance of pancreatic tumor cells to oncologic treatment. PDAC cells have accumulated different molecular mechanisms, which enable survival against cytotoxic therapies. Defects of the apoptosis pathway play a crucial role. For the last 10 years, many investigations were underway to get insights into the details of the anti-apoptotic mechanisms of PDAC cells. The present review provides a comprehensive description of the molecular signaling of the apoptotic pathway, an incentive on the potential pathogenetic role of different molecular defects on existing oncologic treatments and an appraisal of the most recent therapeutic strategies applied at a cell biochemical level.
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Cite this article as:
Ruckert Felix, Pilarsky Christian, Saeger Hans-Detlev and Grutzmann Robert, Apoptotic Signaling in Pancreatic Cancer – Therapeutic Application (Supplemental Data), Current Cancer Therapy Reviews 2009; 5 (2) . https://dx.doi.org/10.2174/157339409788166760
DOI https://dx.doi.org/10.2174/157339409788166760 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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