Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten


Apoptotic Signaling in Pancreatic Cancer – Therapeutic Application (Supplemental Data)

Author(s): Felix Ruckert, Christian Pilarsky, Hans-Detlev Saeger, Robert Grutzmann.


Pancreatic cancer is an exceptionally devastating and incurable disease, the treatment of which has largely been unsuccessful due to the higher resistance of pancreatic tumor cells to oncologic treatment. PDAC cells have accumulated different molecular mechanisms, which enable survival against cytotoxic therapies. Defects of the apoptosis pathway play a crucial role. For the last 10 years, many investigations were underway to get insights into the details of the anti-apoptotic mechanisms of PDAC cells. The present review provides a comprehensive description of the molecular signaling of the apoptotic pathway, an incentive on the potential pathogenetic role of different molecular defects on existing oncologic treatments and an appraisal of the most recent therapeutic strategies applied at a cell biochemical level.

Keywords: Apoptosis pathway, pancreatic cancer, targeted therapy, review

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Article Details

Year: 2009
Page: [122 - 133]
Pages: 12
DOI: 10.2174/157339409788166760
Price: $58