Current Hypertension Reviews

Prof. Kazuomi Kario
Jichi Medical University
School of Medicine
Tochigi
Japan

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Family History and Preclinical Atherosclerosis

Author(s): Silvia Barra, Mario Caprile, Alfredo Madrid, Giovanni Gaeta.

Abstract:

Atherosclerosis is an inflammatory disease which begins in the first decade of life. As clinically apparent atherosclerosis occurs in adulthood, there is a very long time-interval in which arterial wall abnormalities constitute asymptomatic or “preclinical” atherosclerosis. High-resolution B-mode ultrasound constitutes a valid, reliable and inexpensive method for detecting early both structural and functional atherosclerotic changes in the arterial wall. Impaired flowmediated dilation of brachial artery and increased thickness of the intima-media complex of the carotid artery have been found in healthy subjects with risk factors for cardiovascular disease. In this review we evaluated the influence in healthy young subjects of a positive family history of (premature) coronary artery disease, hypertension or type 2 diabetes mellitus on preclinical atherosclerosis.

Keywords: Family history, carotid arteries, atherosclerosis, ultrasound, risk factors

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2009
Page: [94 - 101]
Pages: 8
DOI: 10.2174/157340209788166904
Price: $58