Strategies to Increase the Oral Bioavailability of Nucleoside Analogs

Author(s): Muriel Lalanne, Karine Andrieux, Patrick Couvreur.

Journal Name: Current Medicinal Chemistry

Volume 16 , Issue 11 , 2009

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Abstract:

Nucleoside analogs are first line chemotherapy in various severe diseases: AIDS (acquired immunodeficiency disease syndrome), cytomegalovirus infections, cancer etc. However, most of these compounds suffer from poor bioavailability via oral route. In order to get around this drawback, researchers have imagined many strategies including drug metabolism inhibitors, bio adhesive nanoparticles, amino ester prodrugs, as well as enhancing absorption by increasing drug lipophilicity. This paper illustrated these approaches by developing their application to some nucleoside analogs. Moreover, some of these strategies were very successful and some resulting compounds are now approved by FDA (Food and Drug Administration).

Keywords: Nucleoside analogs, oral absorption, prodrug

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2009
Page: [1391 - 1399]
Pages: 9
DOI: 10.2174/092986709787846550
Price: $58

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