Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry

Author(s): Willy Morelle.

Journal Name: Current Analytical Chemistry

Volume 5 , Issue 2 , 2009

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Abstract:

The determination of post-translational modifications is one of the main challenges in proteomics research. Mass spectrometry is a powerful tool for the structural characterization of proteins and different mass spectrometric techniques for the analysis of post-translational modifications of individual proteins or protein populations have been developed. This review describes the most recent advances in mass spectrometry-based approaches for the detection and determination of post-translational modifications, with an emphasis on glycosylation and phosphorylation.

Keywords: Mass spectrometry, Proteomics, Glycomics, Glycosylation, Phosphorylation, Glycoproteomics, Structural analysis

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2009
Page: [144 - 165]
Pages: 22
DOI: 10.2174/157341109787846153
Price: $58

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