Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100
Italy

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2-Aminoimidazoles from Leucetta Sponges: Synthesis and Biology of an Important Pharmacophore

Author(s): J. D. Sullivan, R. L. Giles, R. E. Looper.

Abstract:

This review will focus on the ability of the 2-aminoimidazole to occupy a unique subset of chemical space which makes it an ideal pharmacophore for the development of small molecule collections for discovery based research. These observations rely both on the use of 2-aminoimidazoles as building blocks in medicinal chemistry as well as the recent discovery of alkaloids from sponges of the genus Leucetta which exhibit a diverse range of biological activities around a relatively limited structural core. The preparation of these compounds will also be highlighted.

Keywords: Review, 2-aminoimidazole, synthesis, biological activity, natural products, naamine, naamidine, isonaamine, isonaamidine, Leucetta, Calcarea

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2009
Page: [39 - 78]
Pages: 40
DOI: 10.2174/157340709787580892