Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Biotechnological Approaches for the Treatment of Inflammatory Diseases

Author(s): V. Iansante, D. Capece, S. Murgo, M. M. Mancarelli, F. Zazzeroni, E. Alesse.

Abstract:

Chronic inflammation represents a key pathogenetic event of many diseases, such as psoriasis, inflammatory bowel diseases, rheumatoid arthritis, asthma, multiple sclerosis, atherosclerosis, cystic fibrosis, and sepsis. Conventional therapies for many of these disorders do not lead to the resolution of the inflammatory disorder, and frequently are associated with limited effectiveness and severe side effects. For these reasons alternative therapies have been developed, in the attempt to ensure a more sustained therapeutic response. Biotechnological approaches for the development of these novel drugs are giving exciting results: several biologic molecules are now tested in preclinical or clinical trials, and several of them are even approved for marketing.

Keywords: Inflammatory diseases, recombinant proteins, nucleic acid-based therapy

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2009
Page: [51 - 71]
Pages: 21
DOI: 10.2174/187152309787580793