Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review

Author(s): Giuseppe Carlucci.

Journal Name:Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 8 , Issue 1 , 2009


High-performance liquid chromatographic methods for the analysis of cyclooxygenase 2 inhibitors (COX-2) in biological fluids are reviewed. In particular, sample preparation and handling procedures, chromatographic conditions and detection methods are discussed. A summary of published high-performance liquid chromatographic assays for individual nabumetone, celecoxib, rofecoxib, nimesulide, etoricoxib, etodolac, deracoxib, lumiracoxib, valdecoxib, and meloxicam is included.

Keywords: Sample preparation, NSAIDs, COX-2 inhibitors, biological fluids, HPLC

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Article Details

Year: 2009
Page: [22 - 37]
Pages: 16
DOI: 10.2174/187152309787580829