Recent Strategies for the Synthesis of Protoberberines and Protoberberine Type Compounds

Author(s): Eberhard Reimann.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 4 , 2009

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Abstract:

The protoberberines are a widespread, important group of isoquinoline alkaloids. Due to the potent pharmacological and other bioactive properties they have achieved an increasing attention in medicinal chemistry and drug research. This article will give a brief structural classification of the protoberberines and related compounds, the biosynthesis, a compilation of new alkaloids isolated during the last decade including source, structure and analytical/spectral data. The main part of the present review is focused on recent synthesis pathways to the title compounds.

Keywords: Synthesis, medicinal chemistry, isoquinoline alkaloids, Protoberberines, analytical/spectral data

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2009
Page: [353 - 378]
Pages: 26
DOI: 10.2174/138527209787582303
Price: $58

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