Cancer Drug Development with the Help of Radiopharmaceuticals: Academic Experience

Author(s): Steven M. Larson.

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 9 , 2009


Abstract:

In the last decade radiotracers have been gradually growing in importance as aids for the development of new drugs. This development has been most pronounced for Psychiatric and Neurologic drugs [1, 2], but has more recently been adapted to the development of drugs against cancer. In this mini-review, we describe how advances in molecular imaging of cancer are likely to lead to advances in development and improved application of anti-cancer drugs [3]. We will focus on 4 aspects of use of radiotracers: 1) for treatment response assessment; 2) for the study of kinetics and pharmacology of novel drugs, including bioavailability and local tumor concentration; 3) the identification of the biologic target at the cellular level; 4) the combination of nanocarriers and radioisotopes to improve biodistribution.

Keywords: Drug Development, radiotracers, molecular imaging, anti-cancer drugs, Cancer Biology

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2009
Page: [950 - 956]
Pages: 7
DOI: 10.2174/138161209787581959
Price: $58

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