Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Antimitotic Chalcones and Related Compounds as Inhibitors of Tubulin Assembly

Author(s): Sylvie Ducki

Affiliation: Laboratoire de Chimie des Heterocycles et des Glucides, ENSCCF, Clermont Universite, 24 avenue des Landais, 63174 Aubiere, France.

Abstract:

The development of chalcones as antimitotic agents has led to the design of other analogues able to interact with tubulin and inhibit its assembly into microtubules. This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents.

Keywords: Chalcone, tubulin, microtubule, antimitotic, cytotoxic

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Article Details

VOLUME: 9
ISSUE: 3
Page: [336 - 347]
Pages: 12
DOI: 10.2174/1871520610909030336
Price: $58