The Contribution of γδ T Cells to the Pathogenesis of EAE and MS

Author(s): Sarah E. Blink, Stephen D. Miller.

Journal Name: Current Molecular Medicine

Volume 9 , Issue 1 , 2009

Become EABM
Become Reviewer

Abstract:

γδ T cells are a multifaceted group of cells which have both innate and adaptive characteristics and functions. Although they are most commonly known for their response to mycobacterium and their locations at mucosal sites, their roles in autoimmunity are still unclear. γδ T cells have been seen in the CSF and lesions of Multiple Sclerosis patients and although their function is not entirely understood, it is clear these cells may have roles in regulating autoimmune inflammation in the CNS. Recent studies have focused on the role of γδ T cells in MS and EAE as both pathogenic and protective, their functions within the CNS, the types of subsets and a possible role in Th17 inflammation. In this review we will examine the data acquired from both human patients and the murine models of MS, experimental autoimmune encephalomyelitis (EAE), in order to gain a clear picture of how γδ T cells influence pathogenesis of EAE and MS.

Keywords: γδ T cells, MS, EAE, IL-17, autoimmunity, CNS

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 9
ISSUE: 1
Year: 2009
Page: [15 - 22]
Pages: 8
DOI: 10.2174/156652409787314516

Article Metrics

PDF: 35