Apoptosis Pathways and Neuroblastoma Therapy

Author(s): S. Fulda .

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 4 , 2009

Abstract:

Evasion of apoptosis, the cells intrinsic death program, is a hallmark of human cancers including neuroblastoma. Also, failure to undergo apoptosis may cause treatment resistance, since the cytotoxic activity of anticancer therapies commonly used in the clinic, e.g. chemotherapy, γ-irradiation or immunotherapy, is predominantly mediated by triggering apoptosis in tumor cells. Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma.

Keywords: Apoptosis, neuroblastoma, TRAIL, caspase-8, Bcl-2, IAPs

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2009
Page: [430 - 435]
Pages: 6
DOI: 10.2174/138161209787315846
Price: $58

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